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ASYMMETRIC MICHAEL ADDITION OF THIOPHENOL TO MALEIC ACID ESTERS
- Source :
- Chemistry Letters. 14:363-366
- Publication Year :
- 1985
- Publisher :
- The Chemical Society of Japan, 1985.
-
Abstract
- (S)-(−)-Diisopropyl phenylthiosuccinate (81% optical purity) is prepared in 95% yield by the asymmetric Michael addition of thiophenol to diisopropyl maleate in the presence of a catalytic amount of cinchonine. The succinate thus prepared is transformed into (R)-(+)-3,4-epoxy-1-butanol without racemization.
Details
- ISSN :
- 13480715 and 03667022
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Chemistry Letters
- Accession number :
- edsair.doi...........65e654457a79f3c5b8f05875eb6f768d