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[Untitled]
- Source :
- Neurochemical Research. 26:533-537
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- We have previously demonstrated that neuropeptide-EI, at high doses, stimulates the production of cAMP, in caudate putamen, through the activation of adenylate cyclase coupled to specific D1 receptors. The aim of the present work was to find evidences for a probable interaction between this neuropeptide and the dopamine D1 receptor in the mammalian central nervous system. The present data show that neuropeptide-EI, at high concentrations, affected both the maximum binding and the apparent affinity of [n-methyl-3H] (R)-(+)-8 chloro-2,3,4,5- tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hemimaleate to the dopamine D1 receptor in a concentration-dependent manner.
- Subjects :
- medicine.medical_specialty
SCH-23390
Neuropeptide
General Medicine
Biology
Biochemistry
Cyclase
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Dopamine receptor D1
Endocrinology
chemistry
Dopamine
D2-like receptor
Internal medicine
Dopamine receptor D2
medicine
Receptor
medicine.drug
Subjects
Details
- ISSN :
- 03643190
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Neurochemical Research
- Accession number :
- edsair.doi...........65ada7d9406965d8b64bf6ed690d1c07