ChemInform Abstract: Novel Protein Kinase C Inhibitors: Synthesis and PKC Inhibition of β-Substituted Polythiophene Derivatives

A series of β-substituted polythiophene derivatives was synthesized through palladium-catalyzed coupling reaction. Their structure-protein kinase C (PKC) inhibitory activity relationship was studied. The carboxaldehyde and hydroxymethyl derivatives of α-terthiophene were potent PKC inhibitors (IC 50 = 10 −7 M).