DIFFERENT CONTRIBUTION OF SARCOMERE AND MITOCHONDRIA RELATED GENE MUTATIONS TO HYPERTROPHIC CARDIOMYOPATHY

Authors :: Se-Joong Rim
Young Won Yoon
Pil-Ki Min
Hyemoon Chung
Hyuck Moon Kwon
Bum-Kee Hong
Jong Youn Kim
Eui-Young Choi
Byoung Kwon Lee
Source :: Journal of the American College of Cardiology. 71:A901
Publication Year :: 2018
Publisher :: Elsevier BV, 2018.
Abstract: In hypertrophic cardiomyopathy (HCM), main genetic interest has been almost limited to sarcomere gene. However, mitochondrial DNA (mtDNA) or related nuclear DNA (nDNA) also contribute to cardiac energy metabolism and hypertrophy. Here, we aimed to identify the sarcomere gene and mitochondria related

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