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3-Hydroxy-propionic Acid

3-Hydroxy-propionic Acid

Authors :
Shadab Ahmed
Vinod Kumar Yata
Jagan Mohan Rao Tingirikari
Publication Year :
2016
Publisher :
Elsevier, 2016.

Abstract

3-Hydroxy-propionate (3-HP) as a bio-based platform chemical has generated a growing interest, largely due to its applications in the synthesis of novel petrochemical-based polymer materials, surgical biocomposite materials, and as a drug release material. 3-HP, a nonchiral organic acid, is ranked third among the top 12 platform chemicals derived from biomass. Many chemical processes have been suggested, but none are commercially feasible at present due to the high cost of the starting materials and process and/or the environmental incompatibility. 3-HP is formed as an oxidation product of 3-Hydroxypicolinic acid; however, its accumulation as a product of glycerol metabolism had not been reported until recently. The biological production of 3-HP using recombinant strains of Escherichia coli and Klebsiella pneumoniae in the presence of glucose or glycerol as potential substrates has also generated interest. The present chapter describes the importance and microbial production of 3-HP, potential feedstocks, and commercial applications.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........64b6c6aee88ebb7a9d6f996afc9fc2c5
Full Text :
https://doi.org/10.1016/b978-0-12-802980-0.00006-7