Allometric scaling of preclinical pharmacokinetic and toxicokinetic parameters to predict clinical pharmacokinetics of BXQ-350 saposin C protein-phosphatidylserine nanovesicles

Authors :: Robert Wesolowski
Gary A. Thompson
John C. Morris
Vinay K. Puduvalli
Trisha Wise-Draper
Olivier Rixe
Angela N. Johnson
Charles A Cruze
John L. Villano
Source :: Journal of Clinical Oncology. 36:e14537-e14537
Publication Year :: 2018
Publisher :: American Society of Clinical Oncology (ASCO), 2018.
Abstract: e14537Background: Interspecies allometric scaling is used to extrapolate pharmacokinetics (PK) from preclinical data to human PK and dosing. Efficacy of BXQ-350, a novel Saposin C phosphatidylserin...

Subjects :: Cancer Research
business.industry
Phosphatidylserine
Pharmacology
Preclinical data
C protein
chemistry.chemical_compound
Oncology
Pharmacokinetics
chemistry
Medicine
Toxicokinetics
Dosing
business

Tools