Hypolipidemic activity of Lannea coromandelica Houtt. leaves in Triton X-100 induced hyperlipidemic rats

Lannea coromandelica Houtt have multiple pharmacological activities including anti-inflammatory, aphrodisiac hypotensive, anti microbial, ulcerative stomatitis, wound healing, leprosy, gout, elephantiasis and cholera. Therefore, the present study is taken up to evaluate the hypolipidemic activity of ethanolic leaf extract of L.coromandelica. The ethanolic leaf extract was evaluated for its acute toxicity (2000mg/kg) and for hypolipidemic activity (100 and 200 mg/kg) in Triton X-100 (100mg/kg, i.p) induced model for 7 days. However, the obtained statistical data indicated a significant decrease in the total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and increase in the HDL cholesterol, with reference to the standard drug Atorvastatin (10mg/kg,p.o). These results revealed that L. coromandelica has beneficial effect in reducing the blood lipid levels indicating its efficient hypolipidemic activity. Keywords: Lannea coromandelica, Atorvastatin, Triton-X, Hyperlipidemia.