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Production of active oxygen and cytotoxicity of tumor cells on pulse laser photodynamic therapy
- Source :
- Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136).
- Publication Year :
- 2002
- Publisher :
- IEEE, 2002.
-
Abstract
- In this study, a doubled Q-switched Nd:YAG laser which has high peak power and lower thermal effect than that of a continuous wave laser, was employed to investigate the damage of tumor cells. As a photosensitizer, zinc coproporphyrin III (Zn CP-III) was prepared. Active oxygen from the photosensitizer was detected by method of luminol chemiluminescence at 430 nm-wavelength. Viability of human small cell carcinoma (MS-1) against the irradiation time, the concentration of Zn CP-III and the pulse energy was investigated. As the result, Zn CP-III produced active oxygen and cells treated by PDT showed a significant reduction of viability.
Details
- Database :
- OpenAIRE
- Journal :
- Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)
- Accession number :
- edsair.doi...........63ff76c8b2d1ec42eacf3f792b0a2223