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Comparative Effects of Dexmedetomidine and Propofol on US-Guided Radiofrequency Ablation of Hepatic Neoplasm Under Monitored Anesthesia Care
- Source :
- Medicine. 94:e1349
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Percutaneous radiofrequency ablation (RFA) is a useful and safe procedure for treating hepatic neoplasm. However, liver RFA causes severe pain, which thereby increases the demand for monitored anesthesia care (MAC). Here, we compared the efficacy and safety of propofol and dexmedetomidine, which are commonly administered during MAC when performing RFA to assess hepatic neoplasm.In this randomized controlled trial, 40 patients were randomly allocated to 2 groups for elective RFA. Patients received either dexmedetomidine (group D) or propofol (group P). Both groups received the continuous infusion of remifentanil for pain control. The primary outcomes were opioid consumption and differences in partial pressure of arterial carbon dioxide (PaCO2) between pre- and postprocedure RFA. In addition, hemodynamic parameters, patient satisfaction, and interventional radiologist satisfaction were determined.There were significant differences in opioid consumption (50.1 ± 16.8 ng/kg/min [group D] vs 71.2 ± 18.7 ng/kg/min [group P]; P = 0.001) and delta PaCO2 (10.4 ± 6.4 mm Hg vs 17.2 ± 9.2 mm Hg, respectively; P = 0.016). Moreover, respiratory rates were significantly different between groups during RFA (P
- Subjects :
- medicine.medical_specialty
business.industry
Radiofrequency ablation
Remifentanil
Hemodynamics
General Medicine
law.invention
Surgery
surgical procedures, operative
Patient satisfaction
Blood pressure
Randomized controlled trial
law
Anesthesia
medicine
Dexmedetomidine
Propofol
business
therapeutics
medicine.drug
Subjects
Details
- ISSN :
- 00257974
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi...........63c67db35a3a37d7c623ad2356c36f12