Are Physical Activity Associations with Bone Mineral Density Modified by Metabolic Traits?

We assessed the relationship of physical activity with BMD at various sites (by DEXA), and examined potential modifying factors, including insulin sensitivity by euglycemic clamp in 765 healthy subjects. Responses from physical activity questionnaires were used to determine total physical activity (PA), moderate physical activity (mod-PA), and sedentary time. Neither activity nor sedentary time correlated with rib, L-spine, or T-spine BMD in univariate analysis (Table). Significant univariate variables were included in multivariate analyses. In multivariate analyses of arm BMD, only female sex (β=-0.74, P Disclosure A. Buttan: None. X. Guo: None. Y. Chen: None. W. Hsueh: Advisory Panel; Self; Merck & Co., Inc., AstraZeneca, Novo Nordisk Inc.. J.I. Rotter: None. M.O. Goodarzi: None.