Abstract 290: Concurrent Gout is Associated with Reduced In-hospital Mortality Among Postmenopausal Women with Acute Myocardial Infarction: Insights from a Nationwide Sample

Background: Gout has been shown to increase the risk of cardiovascular diseases among postmenopausal women. The mechanisms remain unclear. We sought to evaluate in-hospital outcomes among postmenopausal women hospitalized with coexisting gout and acute myocardial infarction (AMI). Methods: Data was retrieved from the Nationwide Inpatient Sample (NIS), using ICD-9-CM codes. We excluded women less than 55yrs old. Patients with acute myocardial infarction (AMI) and co-occurring gout were compared with those without gout. We then tested for associations with stroke, in-hospital mortality and length of stay using multivariate analysis to adjust for confounders. All analyses were performed using SAS. Results: There was a total of 335,403 hospital admissions for AMI. Out of these, 484 had co-occurring gout. Women with both co-occurring conditions were more likely to be white (64.1%). In adjusted models, co-occurring gout and AMI was significantly associated with a reduced likelihood of in-hospital mortality (aOR=0.50, 95% CI: 0.35-0.72, Table 1). However, co-occurring gout and AMI was not significantly associated with stroke rates (aOR=0.95, 95% CI: 0.59-1.55) or length of stay (aOR=1.46, 95% CI: 0.77-2.16). Conclusion: Results from this nationally representative sample suggests that co-occurring gout is associated with reduced in-hospital mortality among postmenopausal women admitted for AMI, while no significant associations were found for length of stay and stroke rates. Further prospective studies are needed to explore these associations.