A phase I dose-finding study of metformin in combination with concurrent cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma

Authors :: J. Silvio Gutkind
Shuchi Gulati
Nooshin Hashemi Sadraei
Sarah Palackdharry
Changchun Xie
Muhammad Kashif Riaz
Vinita Takiar
Michelle Mierzwa
Pankaj B. Desai
Trisha Wise-Draper
Benyamin Yaniv
John C. Morris
Source :: Journal of Clinical Oncology. 36:6074-6074
Publication Year :: 2018
Publisher :: American Society of Clinical Oncology (ASCO), 2018.
Abstract: 6074Background: Up to 60% of HNSCC present as locally advanced disease (LAHNSCC). Although prognosis has improved significantly, 3 year PFS and OS remain at 62%, and 73% respectively (RTOG 0522) de...

Subjects :: Oncology
Cisplatin
Cancer Research
medicine.medical_specialty
business.industry
Locally advanced
medicine.disease
Head and neck squamous-cell carcinoma
Metformin
Dose finding
Internal medicine
Locally advanced disease
medicine
In patient
business
medicine.drug

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