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Perfil clínico de pacientes con miocardiopatía hipertrófica en un hospital universitario
- Source :
- Revista Argentina de Cardiología. 82:366-372
- Publication Year :
- 2014
- Publisher :
- Revista Argentina de Cardiologia, 2014.
-
Abstract
- Introduction: Hypertrophic cardiomyopathy is the most frequent genetic cardiomyopathy and there is no available information on baseline characteristics and outcome of patients with this disease in our country. Objectives: To know the clinical profile of patients with hypertrophic cardiomyopathy and to identify predictors of adverse outcome. Methods: One hundred and forty-three patients with hypertrophic cardiomyopathy at the Hospital Italiano of Buenos Aires between 2005 and 2011 were included in the study. Results: Median age was 66 years and 52% were women. Most patients presented an asymmetric distribution (92%) and 60% had dynamic obstruction. Mortality was 5.59% at a median follow-up of 2.11-years (25-75 IQR: 0.75-3.70). The most prevalent symptom was dyspnea (36%), followed by angina (17%) and syncope (14%). Dynamic obstruction, moderate or severe mitral regurgitation, left atrial diameter and female gender were independently associated with dyspnea. Dynamic obstruction was independently associated with angina. Maximum wall thickness was directly and independently associated with syncope, while ejection fraction and left ventricular hypertrophy or negative T in the electrocardiogram presented an inverse relationship. Mortality was independently associated with hospitalization for decompensated heart failure. Conclusions: Similar to previous studies, our population shows that hypertrophic cardiomyopathy is a heterogeneous disease. A prospective study is necessary to validate the risk predictors assessed in this study.
- Subjects :
- medicine.medical_specialty
education.field_of_study
Ejection fraction
business.industry
Population
Cardiomyopathy
Hypertrophic cardiomyopathy
medicine.disease
Left ventricular hypertrophy
Surgery
Angina
Internal medicine
Heart failure
medicine
Cardiology
Cardiology and Cardiovascular Medicine
education
Prospective cohort study
business
Subjects
Details
- ISSN :
- 18503748 and 00347000
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Revista Argentina de Cardiología
- Accession number :
- edsair.doi...........620985caa11345b887d8cb89762667e2