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CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF FIVE SUBSTITUTED BIS-THIOUREAS
- Source :
- Malaysian Journal of Analytical Science. 20:85-90
- Publication Year :
- 2016
- Publisher :
- Penerbit Universiti Kebangsaan Malaysia (UKM Press), 2016.
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Abstract
- Thioureas play an important role in medicinal chemistry and agricultures due to their biological activity such as antibacterial, antifungal, antiviral, herbicides, rodenticides, phenoloxidase enzymatic inhibitors, anti-HIV and anti-tumor agents. In this study, five substituted bis-thioureas have been synthesized. The isophataloyl chloride and 2,6pyridinedicarbonyl dichloride were easily converted to bis-isothiocyanate compound via the reaction with ammonium thiocyanate by solid–liquid phase transfer catalysis of polyethylene glycol-400 (PEG-400). Bis-isothiocyanate compound was reacted with aniline derivatives to produce substituted bis-thioureas in good yield at room temperature. All the novel compounds were obtained as yellow solid after recrystallization using DMF/EtOH/H2O. Their c h e m i c a l structures were confirmed by Infrared spectrosopy (IR), Nuclear Magnetic Resonance (NMR) H and C and mass spectrometry. The five synthesized compounds were screened for antimicrobial activities using disc diffusion method for antimicrobial activity against Gram-positive bacteria (Bacillus Subtilis and Staphylococcus Aureus), Gram-negative bacteria (Escherichia Coli and Salmonella Typhi) and a mold (Aspergillus Niger). All tested compounds showed low antimicrobial activity since the diameter of inhibition zone (IZ) measure was less than positive control inhibition zone.
- Subjects :
- biology
010405 organic chemistry
Chemistry
Aspergillus niger
Biological activity
Bacillus subtilis
010402 general chemistry
biology.organism_classification
Antimicrobial
01 natural sciences
Chloride
0104 chemical sciences
Analytical Chemistry
chemistry.chemical_compound
Aniline
medicine
Ammonium thiocyanate
Bacteria
medicine.drug
Nuclear chemistry
Subjects
Details
- ISSN :
- 13942506
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Malaysian Journal of Analytical Science
- Accession number :
- edsair.doi...........61b9caa8075a8b3127b44df3aabe35e9