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Aaptamine-Related Alkaloid from the Marine Sponge Aaptos aaptos
- Source :
- Natural Product Communications. 14:1934578X1986393
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- A new aaptamine-related alkaloid, 1,3-dioxolo [4,5- d] benzo [ de]-1,6-naphthyridine (methylenedioxyaaptamine, 1), was isolated from the organic extracts of the Bornean marine sponge Aaptos aaptos, together with a known aaptamine derivative, 8,9,9-trimethoxy-9 H-benzo [ de]-1,6-naphthyridine (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data. Two compounds were tested for their cytotoxic potentials against adult T-cell leukemia (ATL) cells, and compound 1 showed moderate cytotoxic potential.
- Subjects :
- Pharmacology
Aaptos aaptos
biology
010405 organic chemistry
Chemistry
Stereochemistry
Alkaloid
Plant Science
General Medicine
biology.organism_classification
01 natural sciences
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Sponge
Complementary and alternative medicine
Drug Discovery
Subjects
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi...........60ae776facc171074b6393a4d05bd172