Development of an 18F-Labeled Irreversible Inhibitor of Transglutaminase 2 as Radiometric Tool for Quantitative Expression Profiling in Cells and Tissues

Authors :: David Bauer
Robert Wodtke
Markus Laube
Klaus Kopka
Sandra Hauser
Rebecca Rothe
Markus Pietsch
Reik Löser
Jens Pietzsch
Christin Neuber
Johanna Wodtke
Source :: Journal of Medicinal Chemistry. 64:3462-3478
Publication Year :: 2021
Publisher :: American Chemical Society (ACS), 2021.
Abstract: The transamidase activity of transglutaminase 2 (TGase 2) is considered to be important for several pathophysiological processes including fibrotic and neoplastic tissue growth, whereas in healthy ...

Subjects :: integumentary system
biology
Biochemistry
Chemistry
Tissue transglutaminase
Drug Discovery
biology.protein
Molecular Medicine
Quantitative expression
macromolecular substances
Neoplastic tissue

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