INTERMITTENT FASTING IN MICE PROMOTES HISTONE ACETYLATION IN THE PROMOTER REGIONS OF MITOCHONDRIAL ACTIVATING GENES IN THE MUSCLE AND IMPROVES EXERCISE ENDURANCE

Objective:Intermittent fasting (IF) has benefits in increasing insulin sensitivity and lowering body weight. However, the underlining mechanism for the beneficial effects has not been elucidated so far.Design and method:Mice were subjected to a severe IF regimen, in which they were fasted for 72 hou