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Features of the course of the gestational process with the carriage of genotypes F5L:G(1961)A and F2:G(20210)A and inheritance options
- Source :
- Russian Journal of Pediatric Hematology and Oncology. 8:50-58
- Publication Year :
- 2021
- Publisher :
- OOO Grafika, 2021.
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Abstract
- Aim of the study – to establish the features of inheritance of the F5L:G(1961)A and F2:G(20210)A genotypes and to assess their influence on the course and outcomes of pregnancy.Materials and methods. The object of the study was 70 mother–child pairs: 50 women, carriers of the F5L:G(1961)A mutation, and their children; 20 female patients, carriers of the F2:G(20210)A mutation, their children. Additionally, 18 families of women, carriers of the factor V Leiden mutation, in three generations were studied.Results. Carriage of the F5:(1961)GA and F2:(20210)GA genotypes in fetuses is associated with the risk of developing gestational complications in their mothers, which are primarily realized when the maternal laboratory phenotype is manifested. A higher frequency of occurrence of the minor allele A20210 of the FII gene was determined in children than in the older generation (p = 0,0006).
Details
- ISSN :
- 24135496 and 23111267
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Russian Journal of Pediatric Hematology and Oncology
- Accession number :
- edsair.doi...........5fb87d176eb777ae8cc1b035da3bd4dc