ChemInform Abstract: Synthesis of Polysubstituted 2,4-Dimethylquinolines as Potential Antimalarial Drugs

A synthetic way for obtaining 6-amino-2,4-dimethylquinoline derivatives from 2,5-dichloraniline by successive ring closure, nitration, aromatic substitution at so activated quinoline ring, followed by reduction of the nitro group to amino group and alkylation of the last is described.