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Ancillary testing strategies in salivary gland aspiration cytology: A practical pattern-based approach
- Source :
- Diagnostic Cytopathology. 45:808-819
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Fine needle aspiration of salivary gland tumors is a common preoperative triage as it is useful in determining which patients should undergo surgical resection and in guiding the extent of surgery in those cases deemed appropriate for resection. While a specific diagnosis can be achieved on a cytologic specimen in many cases, there is also a considerable amount of morphologic diversity that prevents such confident preoperative classification and in these cases it can be a challenge to confidently determine if a tumor is benign or malignant. Recently, a pattern based risk stratification approach was proposed for salivary gland cytology in which basaloid neoplasms are separated by stromal characteristics and oncocytoid neoplasms are separated primarily by background material such as mucus. In addition to potentially providing a stratification in risk of malignancy for salivary gland tumors, this approach is also useful to narrow differential diagnostic considerations and guide ancillary testing. In this review we use this proposed pattern based approach as a framework to discuss immunostains and fluorescence in situ hybridization studies which we find useful in our practice.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Histology
medicine.diagnostic_test
Salivary gland
business.industry
Risk of malignancy
General Medicine
Pathology and Forensic Medicine
Resection
Aspiration cytology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Fine-needle aspiration
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cytology
Risk stratification
medicine
business
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 87551039
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Diagnostic Cytopathology
- Accession number :
- edsair.doi...........5f9c4a342524d204ef6f70087ed7408b