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Longitudinal OCT tracking of antibiotic treatment response on experimentally induced otitis media

Authors :
Ke Yan
Pawjai Khampang
Ryan G. Porter
Jungeun Won
Darold R. Spillman
Samuels Marshall
Wenzhou Hong
Stephen A. Boppart
Joseph E. Kerschner
Michael A. Novak
Source :
Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology.
Publication Year :
2021
Publisher :
SPIE, 2021.

Abstract

To non-invasively assess the impact of antibiotic therapy on otitis media (OM), a handheld OCT system was developed to longitudinally monitor in vivo middle ear conditions of OM-induced chinchilla models. The formation of middle ear effusions (MEEs) and biofilm were examined over the course of the infection. Furthermore, the effect of antibiotics on the biofilm as well as the amount and type of MEEs was investigated with low-dose and high-dose antibiotics (ceftriaxone). Quantitative parameters, such as TM thickness and effusion and biofilm scattering/texture, were correlated with histology and fluorescence in situ hybridization (FISH) at the end time point.

Details

Database :
OpenAIRE
Journal :
Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology
Accession number :
edsair.doi...........5f795568308d2fa632794b7b7bd2222b
Full Text :
https://doi.org/10.1117/12.2577289