Back to Search Start Over

Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication

Authors :
Filippo Luca Gurgoglione
Andrea Denegri
Michele Russo
Camilla Calvieri
Giorgio Benatti
Giampaolo Niccoli
Source :
International Journal of Molecular Sciences. 24:5155
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Several cardiovascular risk factors are implicated in atherosclerotic plaque promotion and progression and are responsible for the clinical manifestations of coronary artery disease (CAD), ranging from chronic to acute coronary syndromes and sudden coronary death. The advent of intravascular imaging (IVI), including intravascular ultrasound, optical coherence tomography and near-infrared diffuse reflectance spectroscopy has significantly improved the comprehension of CAD pathophysiology and has strengthened the prognostic relevance of coronary plaque morphology assessment. Indeed, several atherosclerotic plaque phenotype and mechanisms of plaque destabilization have been recognized with different natural history and prognosis. Finally, IVI demonstrated benefits of secondary prevention therapies, such as lipid-lowering and anti-inflammatory agents. The purpose of this review is to shed light on the principles and properties of available IVI modalities along with their prognostic significance.

Details

ISSN :
14220067
Volume :
24
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi...........5f3c7dbfec9ecad0ba0bd97a000aed18
Full Text :
https://doi.org/10.3390/ijms24065155