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Synthesis and oligomerization of Nδ-Boc-Nα-(thymin-1-ylacetyl)ornithine
- Source :
- Bioorganic & Medicinal Chemistry Letters. 6:793-796
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- The synthesis of a new DNA analogue based on ornithine is described. Only the thymine analogue was synthesised. A 10 mer entirely made up of the thymine monomer forms a triple helix with poly RNA A. The Tm of the triplex was 21°C.
Details
- ISSN :
- 0960894X
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........5ed1777330c868c0ee74b7e24bf9f8f4
- Full Text :
- https://doi.org/10.1016/0960-894x(96)00121-7