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Copper(I)-Catalyzed Stereoselective Synthesis of (E )-α-Alkynyl-α,β-unsaturated Esters from a Terminal Alkyne, Diazoesters and Aldehydes
- Source :
- Advanced Synthesis & Catalysis. 358:2480-2488
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- A new synthetic method for α-alkynyl-α,β-unsaturated esters is presented herein. The method is based on a copper(I)-catalyzed three-component reaction of a terminal alkyne, diazoesters and aldehydes. The reaction is featured by mild conditions, high yields and excellent stereoselectivity. Cu(I) carbene migratory insertion is proposed as the key step in the transformation.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Chemistry
Migratory insertion
chemistry.chemical_element
Alkyne
General Chemistry
010402 general chemistry
01 natural sciences
Copper
Medicinal chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
Organic chemistry
Stereoselectivity
Carbene
Subjects
Details
- ISSN :
- 16154150
- Volume :
- 358
- Database :
- OpenAIRE
- Journal :
- Advanced Synthesis & Catalysis
- Accession number :
- edsair.doi...........5ec6041c9605203caa1f489fd9bdfc80