Redefining the Limits of Biochemistry in Multidrug Resistant Nematodes: Implications for Future Drug Development

Chemotherapy remains the foremost available tool for the control of nematode parasites. However, the substantial use of anthelmintics, combined with a scarcity of new anthelmintic classes, has led to a gradual increase in the resistance of nematode parasites to these compounds. Multi-Drug Resistance (MDR) in economically important livestock nematodes, such as