Back to Search
Start Over
Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities
- Source :
- Journal of the Brazilian Chemical Society.
- Publication Year :
- 2016
- Publisher :
- Sociedade Brasileira de Quimica (SBQ), 2016.
-
Abstract
- A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N,N-diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.
- Subjects :
- Carbamate
010405 organic chemistry
Chemistry
medicine.medical_treatment
02 engineering and technology
General Chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Combinatorial chemistry
Coupling reaction
0104 chemical sciences
Coupling (electronics)
chemistry.chemical_compound
medicine
0210 nano-technology
Lapachol
Subjects
Details
- ISSN :
- 01035053
- Database :
- OpenAIRE
- Journal :
- Journal of the Brazilian Chemical Society
- Accession number :
- edsair.doi...........5e27749f6d7fb1f7d30602fd2e629b6f
- Full Text :
- https://doi.org/10.21577/0103-5053.20160326