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Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

Authors :
Gardenia C.G. Militão
Alcides J. M. da Silva
Letícia V. Costa-Lotufo
Arinice M. Costa
Paulo R. R. Costa
Edézio Ferreira Cunha-Júnior
Sara L. S. Gomes
Eduardo Caio Torres-Santos
Claudia Pessoa
Source :
Journal of the Brazilian Chemical Society.
Publication Year :
2016
Publisher :
Sociedade Brasileira de Quimica (SBQ), 2016.

Abstract

A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N,N-diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.

Details

ISSN :
01035053
Database :
OpenAIRE
Journal :
Journal of the Brazilian Chemical Society
Accession number :
edsair.doi...........5e27749f6d7fb1f7d30602fd2e629b6f
Full Text :
https://doi.org/10.21577/0103-5053.20160326