Back to Search Start Over

Chem-grafted Zn-SSA as an Efficient Heterogeneous Catalyst to Synthesize 2-Pyridinones

Authors :
Xiang Zhang
Zhen Sheng You
Lijun Zhang
Tian Feng
Wei Li Wang
Heng Li
Source :
Catalysis Letters. 146:2081-2086
Publication Year :
2016
Publisher :
Springer Science and Business Media LLC, 2016.

Abstract

Chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be a high efficient heterogeneous catalyst to solve this problem. Under Zn–SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production. Improving chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be efficient heterogeneous catalyst to solve this problem. Under Zn-SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production.

Details

ISSN :
1572879X and 1011372X
Volume :
146
Database :
OpenAIRE
Journal :
Catalysis Letters
Accession number :
edsair.doi...........5e16dae76bbdfd22bf22d55b3e7e259c
Full Text :
https://doi.org/10.1007/s10562-016-1806-6