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Chem-grafted Zn-SSA as an Efficient Heterogeneous Catalyst to Synthesize 2-Pyridinones
- Source :
- Catalysis Letters. 146:2081-2086
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be a high efficient heterogeneous catalyst to solve this problem. Under Zn–SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production. Improving chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be efficient heterogeneous catalyst to solve this problem. Under Zn-SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production.
- Subjects :
- 010405 organic chemistry
Catalyst support
chemistry.chemical_element
Amorphous silica-alumina
General Chemistry
Zinc
010402 general chemistry
Heterogeneous catalysis
01 natural sciences
Catalysis
0104 chemical sciences
chemistry.chemical_compound
chemistry
Organic chemistry
Lewis acids and bases
Organometallic chemistry
Malononitrile
Subjects
Details
- ISSN :
- 1572879X and 1011372X
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- Catalysis Letters
- Accession number :
- edsair.doi...........5e16dae76bbdfd22bf22d55b3e7e259c
- Full Text :
- https://doi.org/10.1007/s10562-016-1806-6