Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Authors :: Marcel A.G. van der Heyden
Sridharan Rajamani
Alexandre Bossu
Veronique M.F. Meijborg
Rosanne Varkevisser
Albert Dunnink
Nevena Mollova
Marien J C Houtman
Luiz Belardinelli
Jacques M.T. de Bakker
H D M Beekman
Marc A. Vos
Source :: British Journal of Pharmacology. 175:2470-2482
Publication Year :: 2018
Publisher :: Wiley, 2018.
Abstract: © 2018 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Subjects :: 0301 basic medicine
Pharmacology
Drug
business.industry
media_common.quotation_subject
Torsades de pointes
Phenethylamines
030204 cardiovascular system & hematology
medicine.disease
Sodium current
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine
business
media_common

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