Insights into targeting SARS-CoV-2: design, synthesis, in silico studies and antiviral evaluation of new dimethylxanthine derivatives

Authors :: Abdalla R. Mohamed
Ahmed Mostafa
Mahmoud A. El Hassab
Gomaa M. Hedeab
Sara H. Mahmoud
Riham F. George
Hanan H. Georgey
Nagwa M. Abdel Gawad
Mohamed K. El-Ashrey
Source :: RSC Medicinal Chemistry. 14:899-920
Publication Year :: 2023
Publisher :: Royal Society of Chemistry (RSC), 2023.
Abstract: The expanded structure- and ligand-based drug design strategy was utilized to obtain a multitargeting SARS-CoV-2 inhibitor, compound 9a, with an IC50 value of 8.86 μM.

Subjects :: Pharmacology
Organic Chemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Biochemistry

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