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Trudności diagnostyczne u dziewczynki z wieloukładową histiocytozą z komórek Langerhansa – opis przypadku
- Source :
- Pediatria Polska. 90:76-80
- Publication Year :
- 2015
- Publisher :
- Termedia Sp. z.o.o., 2015.
-
Abstract
- Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology and varied picture and clinical course. The intensity and the outcome of LCH treatment depend on the amount and type of the affected organs, their dysfunction and age of the patient. In this paper we present the diagnostic difficulties in a 19-month-old girl with multisystem LCH, manifesting mainly by persistent fever, deep anemia, hepatosplenomegaly and lymphadenopathy, coexisting with EBV infection and urinary tract infection. On diagnosis, LCH was suspected once the bone lesions were detected on CT scans, which, however, were not confirmed in the bone scintigraphy. Histopathological diagnosis of LCH was based on the histopathological examination of the cervical lymph node, in which CD1a expression was detected. Myelogram morphologically was assessed as normal; however, bone marrow smears were respectively found to express CD1a. The patient received aggressive and long-lasting treatment according to the protocol LCH in 2009, yielding a complete clinical remission of LCH.
- Subjects :
- Pathology
medicine.medical_specialty
medicine.diagnostic_test
Anemia
business.industry
Hepatosplenomegaly
medicine.disease
medicine.anatomical_structure
Bone scintigraphy
Langerhans cell histiocytosis
Pediatrics, Perinatology and Child Health
medicine
Etiology
Bone marrow
medicine.symptom
business
Lymph node
Rare disease
Subjects
Details
- ISSN :
- 00313939
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Pediatria Polska
- Accession number :
- edsair.doi...........5cc21ff36569d828273c318518d5e4d9