Abstract 842: Ethnic differences in association of behavioral risk factors with gastric precancerous lesions in Inner Mongolia, China

Background: The prevalence of Gastric precancerous lesion (GPL) exists ethnic differences, however, little evidence exists to clarify whether preventable behavioral risk factors lead to these differences. Objectives: To investigate the ethnic-difference of associations between GPL and behavioral risk factors in Mongol and Han Chinese population. Methods: The study included participants aged 36-75 years enrolling in the Cancer Screening Program during 2016-2017 from Hohhot and Tongliao City in Inner Mongolia. GPL defined as gastric ulcer, atrophic gastritis, intestinal metaplasia and dysplasia. Results: A total of 61638 participants were included, of whom 6863(11.1%) were Mongolians. The prevalence of GPL for Mongolians (13.6%) was significantly higher than that of Han (10.2%). Compared with Han: (1) Mongolians have significantly higher proportion of alcohol consumption (23.1% vs 18.8%), along with a larger positive association for alcohol consumption with GPL, and a higher population attributable fraction (PAF) (P Conclusion: Mongolians should pay more attention to the intervention of behavioral risk factors. Additionally, the result may also reflect a different GPL pathogenesis in Mongolians. Association between behavioral risk factors and GPL in study populationBehavioral risk factorsExposure ratio (%) (95%CI)P for chi-square testOdd Ratio (95%CI )P for interactionPopulation attributable fraction (95%CI )Smoking (cigarettes/d) Citation Format: Weiqi Dong, Liying Qiao, Buqi Na, Weiwei Kang, Shengfeng Wang, Wenrui Wang, Yunfeng Xi. Ethnic differences in association of behavioral risk factors with gastric precancerous lesions in Inner Mongolia, China [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 842.