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Enzymatic resolution of methyl (1RS)-N-tBoc-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate by Seaprose S

Authors :
Ellen K. Kick
Yufeng Wang
Kate Richlin-Zack
Wu Yang
Ramesh N. Patel
Iqbal Gill
Source :
Tetrahedron: Asymmetry. 18:2147-2154
Publication Year :
2007
Publisher :
Elsevier BV, 2007.

Abstract

An efficient biocatalytic process has been developed for the resolution of methyl (1 RS )- N - t Boc-6-hydroxy-3,4-dihydro-1 H -isoquinoline-1-carboxylate rac - 1 by means of Seaprose S-mediated enantioselective hydrolysis to afford (1 S )- 2 and (1 R )- 1 in 87% and 93% isolated yield, 101% and 96% potency, and ee >99.8% and >99.5%, respectively.

Details

ISSN :
09574166
Volume :
18
Database :
OpenAIRE
Journal :
Tetrahedron: Asymmetry
Accession number :
edsair.doi...........5c4a7be98592996bd153a4261182f01c