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Bone metabolic disorders caused by small bowel resection, and the influence of 1α-hydroxyvitamin D3 on the rats
- Source :
- Journal of Bone and Mineral Metabolism. 8:17-25
- Publication Year :
- 1990
- Publisher :
- Springer Science and Business Media LLC, 1990.
-
Abstract
- Metabolic bone disorders caused by resection of the distal three quarters of the small bowel and the effects of 1α-hydroxyvitamin D3 (1α(OH)D3) on the rats were investigated biochemically and histomorphologically. 1α(OH)D3 was administered orally to the rats for 13 weeks. A group of “ sham operation” animals and the 75%-distal-small-bowel-resected control animals received only the vehicle. Bone changes developed 13 weeks after the partial bowel resection. The disorder was characterized by reductions in ash content of the femur and by the disappearance of the trabecular bone in tibial metaphysis.
- Subjects :
- medicine.medical_specialty
Small bowel resection
business.industry
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
General Medicine
Bowel resection
Gastroenterology
Metabolic Bone Disorder
Resection
Trabecular bone
Endocrinology
Tibial metaphysis
Internal medicine
Orthopedic surgery
medicine
Orthopedics and Sports Medicine
Femur
business
Subjects
Details
- ISSN :
- 14355604 and 09148779
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Bone and Mineral Metabolism
- Accession number :
- edsair.doi...........5c2aa387d1933c9937ce9aed7bf18577