Back to Search Start Over

Label-Free and Recalibrated Multilayer MoS2 Biosensor for Point-of-Care Diagnostics

Authors :
Heekyeong Park
Sunkook Kim
Geonwook Yoo
Joonhyung Lee
Hyungbeen Lee
AbdulAziz AlMutairi
Young Jun Kim
Wan-Joong Kim
Seok Hwan Jeong
Muhammad Naqi
Gyuchull Han
Youngki Yoon
Sang Woo Lee
Source :
ACS Applied Materials & Interfaces. 9:43490-43497
Publication Year :
2017
Publisher :
American Chemical Society (ACS), 2017.

Abstract

Molybdenum disulfide (MoS2) field-effect transistor (FET)-based biosensors have attracted significant attention as promising candidates for highly sensitive, label-free biomolecule detection devices. In this paper, toward practical applications of biosensors, we demonstrate reliable and quantitative detection of a prostate cancer biomarker using the MoS2 FET biosensor in a nonaqueous environment by reducing nonspecific molecular binding events and realizing uniform chemisorption of anti-PSA onto the MoS2 surface. A systematic and statistical study on the capability of the proposed device is presented, and the biological binding events are directly confirmed and characterized through intensive structural and electrical analysis. Our proposed biosensor can reliably detect various PSA concentrations with a limit of 100 fg/mL. Moreover, rigorous theoretical simulations provide a comprehensive understanding of the operating mechanism of the MoS2 FET biosensors, and further suggests the enhancement of the sensitivity through engineering device design parameters.

Details

ISSN :
19448252 and 19448244
Volume :
9
Database :
OpenAIRE
Journal :
ACS Applied Materials & Interfaces
Accession number :
edsair.doi...........5bc77d36474d381422ee991735fa6e8b