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Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
- Publisher :
- Public Library of Science (PLoS)
-
Abstract
- The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values
- Subjects :
- 2. Zero hunger
Adult
Male
Menarche
Adolescent
Monosaccharide Transport Proteins
Waist-Hip Ratio
Nedd4 Ubiquitin Protein Ligases
nutritional and metabolic diseases
Cardiometabolic Risk Factors
Blood Pressure
Mendelian Randomization Analysis
3. Good health
Body Mass Index
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Child, Preschool
Humans
Female
Genetic Predisposition to Disease
Child
Genome-Wide Association Study
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........5bc7379ac41b8a71e2bdf0128bfc5c4b