Application of DNA Sequence and Clone Data

The sequence of nucleotides within a DNA molecule can yield a wealth of information. Important biological features such as amino acid sequence, exact amino acid composition, and gene structure are contained within sequences. The data can be used for highly specific manipulations of cloned DNA, such as changing a single nucleotide, substituting promoters between genes, and fusing of genes to yield hybrid (heterologous) proteins. Probes can also be designed for a variety of uses, including the detection of genetic diseases and pathogenic microbes.