Back to Search Start Over

Effects of prophylactic palonosetron combined with low dose droperidol on the QTc interval: a randomized controlled trial

Authors :
Zhijia Guo
Chenggang Wang
Dongdong Bai
Chunyan Wang
Shouyuan Tian
Jieping Lv
Shuwei Luan
Wenjie Zhang
Publication Year :
2022
Publisher :
Research Square Platform LLC, 2022.

Abstract

Objective To study the effect on QTc intervals in patients who are undergoing surgery and receive palonosetron combined with low-dose droperidol.Methods Our study included 60 patients who were undergoing laparoscopic surgery under hysteroscope. The patients were randomly assigned to two groups: those who received an i.v. injection of droperidol 1 mg (F group, n=30) and those who received palonosetron 0.075 mg and droperidol 1 mg (P+F group, n=30) at 5 min after tracheal intubation. Mean arterial pressure, heart rate, bispectral index (BIS) and QTc intervals were measured before (T0) and 5 (T1), 10 (T2), and 20 min (T3) after administration of droperidol or palonosetron plus droperidol. QTc intervals were measured and calculated according to the correction formulas. The severity of postoperative nausea and vomiting and the incidence of other adverse effects in patients at 24 h after surgery were recorded.Results At T1, the QTc intervals of F group and P+F group were significantly prolonged from the T0 values (P < 0.05); at T0~T3, there was no statistically significant difference in the comparison of the changes of heart rate, mean arterial pressure, BIS, and QTc intervals between the two groups (P > 0.05); the severity of nausea and vomiting at 24h postoperatively in the P+F group was lower than that in the F group (P < 0.05); there was no significant difference in the incidence of other postoperative adverse reactions between the two groups (P > 0.05). Conclusion There was no significant difference in the QTc intervals during the perioperative period, whether 1 mg of droperidol or 1 mg of droperidol plus 0.075 mg of palonosetron is administered. And the severity of postoperative nausea and vomiting in patients who received palonosetron combined with low-dose droperidol was lower than those who received droperidol.Trial Registration Chinese clinical trial registry, ChiCTR2000029678, 09/02/2020

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........5b2613802bd653fcdd7eef0599fb9127
Full Text :
https://doi.org/10.21203/rs.3.rs-1259402/v1