POS0279 THE ABCG2 rs2231142 POLYMORPHISM ARE ASSOCIATED WITH RISK OF NEPHROLITHIASIS IN A TAIWANESE POPULATION

BackgroundIn genome-wide association studies (GWAS), the strong association of ABCG2 rs2231142 variant with hyperuricemia and gout was confirmed in Asian population. Additionally, the obesity, diet, lifestyle, genetics and underlying comorbidities are important risks factors predisposing to hyperuricemia and gout. The systematic reviews revealed a significant link between obesity, systemic comorbidities and hyperuricosuria for predisposition of kidney stones (nephrolithiasis). However, whether ABCG2 plays an important role in the phathogenesis of nephrolithiasis remain unclear. The interaction between genetic factors and other risk factors of nephrolithiasis is still elusive.ObjectivesIn this study, we want to explore the association between ABCG2 rs2231142 variant and the risk of nephrolithiasis in modern Taiwanese population, and clarify the role of uric acid in nephrolithiasis formation.MethodsThis retrospective case-control study was conducted using the Taiwan Biobank database. A total of 120,267 individuals of Taiwanese Han Chinese aged 30-70 years were enrolled in the study. The primary outcome was the incidence of self-reported nephrolithiasis. Odds ratio (OR) of incident nephrolithiasis was analyzed by multiple logistic regression models and the interaction between ABCG2 rs2231142 variants, serum uric acid level, on the nephrolithiasis was explored. The multifactorial confounding factors for prediction of nephrolithiasis were also re-examined in our study.ResultsFinally, we identified 8,410 participants with nephrolithiasis and the prevalence was 11.52% and 4.37% in men and women, respectively. Older age (OR=1.08, 95% CI: 1.02-1.03, ppppppp=0.002), and hyperuricemia (OR=1.06, 95% CI: 1.04-1.08, pppp=0.083). Participants with regular physical exercise is a protective factor from nephrolithiasis (OR=0.95, 95% CI:0.9-1.0, p=0.048).ConclusionOur study demonstrated the risk of nephrolithiasis is significant association with ABCG2 rs2231142 variants. This risk also increased with systemic comorbidities (hyperlipidemia, hypertension, diabetes mellitus, and hyperuricemia), and lifestyle (obesity, and smoking). Regular physical exercise is associated with protective factor for incident nephrolithiasis.Table 1.Adjusted Odds ratio of kidney stone.VariableOR95% CIp-valueAge, years1.03(1.02-1.03)Gender female1.00—— male2.21(2.08-2.36)ABCG2 rs2231142 GG1.00—— GT1.12(1.06-1.18) TT1.18(1.09-1.28)Hyperlipidemia No1.00—— Yes1.40(1.29-1.51)Hypertension No1.00—— Yes1.67(1.57-1.78)Diabetes No1.00—— Yes1.16(1.06-1.26)0.002Hyperuricemia >7.0 mg/dL No1.00—— Yes1.06(1.04-1.08)Smoking No1.00—— Yes1.15(1.09-1.22)Alcohol use No1.00—— Yes0.92(0.84-1.01)0.083Regular physical exercise No1.00—— Yes0.95(0.90-1.00)0.048Overweight, BMI ≥24 kg/m2 No1.00—— Yes1.22(1.15-1.28)OR was adjusted for all variables in table.Disclosure of InterestsNone declared