COAGULATION STUDIES ON THORACIC DUCT LYMPH IN HYPOVOLEMIC SHOCK DOGS

Publisher Summary This chapter focuses on coagulation studies on thoracic duct lymph in hypovolemic shock dogs. Progressive interstitial edema following increased microvascular permeability is a central feature in the disseminated intravascular coagulation. The chapter describes a study in which 50 ml blood per minute was taken from 20 healthy adult Basset dogs under pentobarbital narcosis from the right femoral artery up to an arterial mean blood pressure of 40 mm Hg, with simultaneously measuring of arterial and central venous blood pressure and monitoring of EGG. Thoracic duct lymph is normally known to have coagulation properties, but the coagulation activity is significantly lower than that of plasma. Endogenous coagulation factors are a good tool to study the relationship between molecular size and transcapillary escape. The increase activities of coagulation factors in lymph might arise from an increased transcapillary filtration, from mobilization of factors out of extravascular pools by a washout and extravascular partial activation of some factors, and from a decreased peripheral lymph flow.