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Performance of IgG avidity in an area endemic for schistosomiasis in Egypt
- Source :
- Eastern Mediterranean Health Journal. :172-180
- Publication Year :
- 2002
- Publisher :
- World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO), 2002.
-
Abstract
- We assessed the performance of IgG avidity in the diagnosis of acute, chronic and recent [reinfection] on top of chronic schistosomal infections in patients treated with praziquantel. Immunoglobulin levels were studied in 111 patients with Schistosoma mansoni infection and 28 partially cured patients [not responding to the first dose of praziquantel treatment and almost cured after a second one]. Before treatment all patients with schistosomiasis had elevated IgG levels, 75% of them also had increased IgM levels. Avidity index was high among all age groups. The increased IgM/IgG ratio and avidity index among children with schistosomiasis before treatment support the idea of reinfection. Treatment had no significant effect on the studied parameters. We conclude that unlike IgM and IgG antibody levels, IgG avidity test cannot be used to distinguish between recent and chronic infections.
- Subjects :
- biology
business.industry
Increased IgM level
chemical and pharmacologic phenomena
Schistosomiasis
General Medicine
biology.organism_classification
medicine.disease
Immunoglobulin G
Praziquantel
Immunoglobulin M
parasitic diseases
Immunology
biology.protein
Medicine
Avidity
Schistosoma mansoni
Antibody
business
medicine.drug
Subjects
Details
- ISSN :
- 16871634 and 10203397
- Database :
- OpenAIRE
- Journal :
- Eastern Mediterranean Health Journal
- Accession number :
- edsair.doi...........5a6ed17fb2268265592f398d91c8526a