Ethyl Acetate Chemical Sensor as Lung Cancer Biomarker Detection Based on Doped Nano-SnO₂ Synthesized by Sol-Gel Process

In this paper, we have studied the feasibility of developing an Ethyl acetate sensor as a biomarker for early detection of lung cancer in the form of a chemical sensor. For this we report the effect of Ni and Cu doping on the electrochemical characteristics of the SnO2 nanomaterial synthesized by sol-gel method. Formation of composite nanomaterial of undoped/doped SnO2 was confirmed by structural, morphological and elemental characterization and used as matrix for ethyl acetate (EA) chemical sensor in the form of screen-printed electrode (SPE). Conventional electrochemical techniques such as cyclic voltammetry (CV), scan rate studies and impedance spectroscopic studies were conducted for several EA concentration from 1 to 20 ppb prepared in phosphate buffer solution (PBS). CV results shows a well-defined oxidation and reduction peak at different potential with different doping. The estimated sensitivity values for pristine SnO2 is $0.3\mu \text{A}$ /ppb, for NiSnO2 is $2.3~\mu \text{A}$ /ppb and for CuSnO2 is $4.8~\mu \text{A}$ /ppb when estimated over the wider range from 1ppb to 20ppb. Selectivity study was also conducted that showed selective response to EA.