Back to Search
Start Over
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
- Source :
- Journal of Medicinal Chemistry. 62:8711-8732
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
- Subjects :
- 0303 health sciences
Catechol
Allosteric modulator
Stereochemistry
Subtype selective
01 natural sciences
0104 chemical sciences
010404 medicinal & biomolecular chemistry
03 medical and health sciences
chemistry.chemical_compound
Dopamine receptor D1
chemistry
Dopamine
Drug Discovery
medicine
Molecular Medicine
Hydroxymethyl
030304 developmental biology
medicine.drug
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi...........5a353395d3c6f7ca6dfa78c95a347dd4