The Synthesis ofN-Glycosyl-N′-Pyrazolylmethylene Aminothioureas under a 4Å Molecular Sieve

A series of novel N-glycosyl-N'-pyrazolylmethylene aminothioureas (4a-4e, 5a-5e) were synthesized from N-glycosyl-N'-aminothioureas (2a-2d) and 4-formylpyrazole (3a-3e). Activated 4A molecular sieves were adopted for dehydrated reagent to improve the reaction rate and yield. The structures of the new compounds were identified on the basis of IR, 1 H NMR and MS spectra. Simultaneously, the compounds were detected by fluorescence spectrophotometer and had preferable fluorescence activity, so they can be selected as a kind of novel fluorescence labeled derivative of sugar.