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Capacitive Detection of Morphine via Cathodically Electropolymerized, Molecularly Imprinted Poly( p ‐aminostyrene) Films
- Source :
- Macromolecular Chemistry and Physics. 217:1810-1822
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly(p aminostyrene). Through molecular imprinting, morphine-specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20–40 × 10−6 m concentrations and a detection limit of 5.95 × 10−6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical-quartz crystal microbalance and characterized by X-ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen-bonding interactions between the monomer, cross-linker, and analyte form a stable pre-polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte.
- Subjects :
- Analyte
Materials science
Polymers and Plastics
Inorganic chemistry
Analytical chemistry
Infrared spectroscopy
02 engineering and technology
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
X-ray photoelectron spectroscopy
Polymer chemistry
Materials Chemistry
Molecule
Physical and Theoretical Chemistry
chemistry.chemical_classification
Detection limit
Organic Chemistry
Polymer
021001 nanoscience & nanotechnology
Condensed Matter Physics
0104 chemical sciences
Monomer
chemistry
0210 nano-technology
Molecular imprinting
Subjects
Details
- ISSN :
- 15213935 and 10221352
- Volume :
- 217
- Database :
- OpenAIRE
- Journal :
- Macromolecular Chemistry and Physics
- Accession number :
- edsair.doi...........59830ad038861a126e29e692b60bbb92