ATIII und NAC hemmen die mikrovaskuläre Thrombusbildung im postischämischen Gewebe in vivo

Combined pancreas-kidney transplantation is one therapeutic option of Diabetes mellitus. In the early postoperative period pancreatic venous thrombosis is one of the major complications leading to allograft dysfunction and graft loss. One risk factor is the ischemia-reperfusion(I/R)- injury. Additionally, immunosuppressive drugs, such as the calcineurine inhibitor tacrolimus, have been implicated in the development of microvascular thrombosis. Several studies report a beneficial effect of antithrombin III (ATIII)- and N-acetylcysteine-(NAC)-substitution on the ischemia-reperfusion injury. Aim of this study was to analyse the therapeutic effect of ATIII and NAC on microvascular thrombus formation in post-ischemic tissue under immunosuppressive therapy with tacrolimus in vivo.