Analogues of Hybrid Antimicrobial Peptide, CAMA-P2, Designed with Improved Antimicrobial and Synergistic Activities

E-mail: ymkim@konkuk.ac.krReceived May 16, 2011, Accepted June 15, 2011We have designed a 20-residue hybrid peptide CA(1-8)-MA(1-12) (CAMA) incorporating residues 1-8 ofcecropin A (CA) and residues 1-12 of magainin 2 (MA) with high bacterial cell selectivity. CAMA-P2 is an α-helical antimicrobial peptide designed from a CAMA hybrid peptide and substitution of Gly-Ile-Gly hingesequence of CAMA to Pro influences the flexibility at central part of CAMA. Based on structure-activityrelationships of CAMA peptides, to investigate the effects of the total positive charges on antimicrobial activityof CAMA-P2, the Ser