Cy5-Labeled Phosphatidylcholine

Fluorescent lipid probes are widely used as tools for studying the properties of biological membranes and for studies of such biological functions of lipids as metabolic pathways and the molecular nature of diseases. In this report, we propose the new Cy5-labeled phosphatidylcholine (Cy5-PC) fluorescent lipid probe and describe its geometrical parameters, its synthesis, its spectral characteristics, and data on its mobility in a lipid membrane. Су5-PC is an excellent probe for bioimaging, because the intensity of its fluorescence retains a linear dependence up to high concentrations. However, the use of Су5-PC in studies of membrane dynamics is impossible, since the probe is insensitive even to the phase transition in a lipid membrane.