Back to Search
Start Over
P1‐221: RELATIONSHIP BETWEEN CEREBRAL BLOOD FLOW AND CORTICAL LAYER I ASTROCYTES IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE
P1‐221: RELATIONSHIP BETWEEN CEREBRAL BLOOD FLOW AND CORTICAL LAYER I ASTROCYTES IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE
- Source :
- Alzheimer's & Dementia. 10
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- (WT) mice (n1⁄48) were studied at 17-19 months-of-age. Whole brain perfusion images (360 mm isotropic spatial resolution) were acquired with a multi-slice, pseudocontinuous ASL pulse sequence on a 7T animal MRI system. Mice were scanned both in the awake state and under sevoflurane anesthesia (a known vasodilator) to assess group differences in resting CBF and vasodilatory response, respectively. The perfusion images were co-registered to anatomical MR images acquired during the same session, and spatially normalized to reference coordinate space to generate regional perfusion measures using a fully-automated image processing pipeline (NIGHTWING TM, Biospective Inc.). Results: The Tg mice exhibited a lower resting CBF (w15%) compared to theWTmice in most brain regions. Under sevoflurane, this difference increased tow30% as the Tgmice exhibited an attenuated vasodilatory response relative to the WT group. The coefficient of variation was higher in the awake mice. Conclusions: This study demonstrated that APPoverexpressing Tg mice have impaired resting cerebrovascular function, which is exacerbated under a challenge condition. The greater effect size of the challenge state suggests that utilization of an appropriate vasodilatory challenge could be a useful paradigm in human AD studies.
- Subjects :
- Genetically modified mouse
medicine.medical_specialty
Epidemiology
business.industry
Health Policy
Coefficient of variation
Vasodilation
Perfusion scanning
Sevoflurane
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Developmental Neuroscience
Cerebral blood flow
Internal medicine
medicine
Cardiology
Neurology (clinical)
Geriatrics and Gerontology
business
Perfusion
Neuroscience
medicine.drug
Sevoflurane anesthesia
Subjects
Details
- ISSN :
- 15525279 and 15525260
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia
- Accession number :
- edsair.doi...........58f6e6d3a4378bd935fd6ce122b0ef58
- Full Text :
- https://doi.org/10.1016/j.jalz.2014.05.460