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Ganciclovir: a promising topical antiviral gel for herpetic keratitis
- Source :
- Expert Review of Ophthalmology. 4:367-375
- Publication Year :
- 2009
- Publisher :
- Informa UK Limited, 2009.
-
Abstract
- Ganciclovir (GCV) is a potent broad-spectrum antiviral with proven efficacy against herpes viruses. As it inhibits viral but not cellular DNA, it is expected to avoid the toxicity associated with trifluridine – the only currently approved treatment for herpes simplex keratitis in the USA. Preclinical studies have demonstrated GCV to be as effective as trifluridine against experimental herpes simplex keratitis. Clinical studies conducted in Europe, Asia, and Africa that compared the efficacy and tolerability of GCV ophthalmic gel with acyclovir (ACV) ophthalmic ointment in patients with herpetic keratitis showed that GCV-treated patients had higher overall healing rates and lower relapse rates than ACV-treated patients. The ganciclovir gel formulation was also much better tolerated than the ACV ointment base. Finally, a controlled, masked, randomized series of 18 patients with adenoviral keratoconjunctivitis compared GCV gel with preservative-free artificial tears. Ganciclovir-treated patients experienced ...
- Subjects :
- Ganciclovir
medicine.medical_specialty
business.industry
viruses
medicine.medical_treatment
Biomedical Engineering
virus diseases
Trifluridine
medicine.disease_cause
medicine.disease
Dermatology
Virology
Keratitis
Ophthalmology
Artificial tears
Herpes simplex virus
Tolerability
Adenoviral keratoconjunctivitis
medicine
business
Keratoconjunctivitis
Optometry
medicine.drug
Subjects
Details
- ISSN :
- 17469902 and 17469899
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Expert Review of Ophthalmology
- Accession number :
- edsair.doi...........5871200a915ffa0fd1ea213c377baea7
- Full Text :
- https://doi.org/10.1586/eop.09.25