Ring size effect in the PKC inhibitory activities of perhydroazepine analogs of balanol

Authors :: Steven E. Hall
Frankie Mylott
Yen-Shi Lai
David S. Menaldino
G. Erik Jagdmann
Jeffrey B. Nichols
Jan E. Gillespie
Source :: Bioorganic & Medicinal Chemistry Letters. 5:2151-2154
Publication Year :: 1995
Publisher :: Elsevier BV, 1995.
Abstract: Analogs 3–5 of balanol (−)- 1 , a potent protein kinase C (PKC) inhibitor, were synthesized with the perhydroazepine moiety replaced by a smaller ring. Their in vitro inhibitory activities against PKC revealed a significant relationship between ring size and potency.

Subjects :: Chemistry
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Inhibitory postsynaptic potential
Ring (chemistry)
Biochemistry
In vitro
Balanol
Ring size
chemistry.chemical_compound
Drug Discovery
Molecular Medicine
Moiety
Potency
Molecular Biology
Protein kinase C

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